A team of researchers has found that by removing senescent cells, it may bring us one step closer to the “fountain of youth”.However, experts warned that an anti-ageing serum could be a few years off yet as the drugs may be unsafe for elderly people.
A drug has previously been found to help elderly mice regrow their hair, run faster and live for longer. It works by removing cells in skin tissue that naturally accumulate as the rodents grow older.
But the senescent cells – which are unable to reproduce themselves and prevent tissue growth – are also found in humans. The study was published in the journal Trends in Molecule Medicine.
“This strategy may bring us one step closer to the ” fountain of youth,” but it’s important to be cautious and not hype,” said researcher of aging Peter de Keizer of the Erasmus University Medical Center in the Netherlands.
They noticed that these permanently arrested cells accumulate in mature tissue and that some of them secrete factors that are harmful to tissue function and impair their neighboring cells.
To explain what causes this noise in the system, de Keizer proposes a “senescence-stem lock model” in which the chronic secretion of pro-inflammatory factors by these senescent cells keeps neighboring cells in a permanent stem-like state and thereby prevents proper tissue renewal.”
There’s still much basic research to be done before humans visit their local rejuvenation clinic for their annual shot of anti-aging serum.
That being said, these are clearly very exciting times, and I am confident we will find applicable anti-senescence treatments that can counteract age-related pathologies,” de Keizer explained.
De Keizer, who plans to co-found a start-up based on the discovery of anti-senescence compounds from his lab, is hopeful that cell-penetrating peptides that can block specific activities of these retired cells could be the path forward over broad-range inhibitors.